@article { author = {Budak Diler, Songül and Aybuğa, Fatma}, title = {Association of Autophagy Gene ATG16L1 Polymorphism with Human Prostate Cancer and Bladder Cancer in Turkish Population}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {9}, pages = {2625-2630}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.9.2625}, abstract = {Background: Urological cancers (prostate cancer and bladder cancers) are the most common cancers in Westernpopulation and its rate is increasing in the Eastern World. Autophagy has appeared as a fundamental repair mechanismfor degrading damaged organelles and proteins. It was clear that autophagy gene polymorphisms are correlated withdevelopment of inflammatory bowel disease and it can also be related with prostate cancer (PCa) or bladder cancer(BCa). In this study, we aimed to determine if ATG16L1 (Thr300Ala) polymorphism is associated with an increased riskof developing PCa and BCa and to establish correlations between ATG16L1 genotypes and morphological parameters.Methods: This study included 269 healthy controls and 131 patients (62 PCa and 69 BCa) with PCa and BCa. TheATG16L1 (rs2241880) gene regions were amplified using polymerase chain reaction (PCR), detected by restrictionfragment length polymorphism (RFLP). Results: At the end of our research, we found out that the genotype AG wasprevalent on patients and controls (34% vs 42%), followed by genotypes AA (35% vs 27%) and GG (31% vs 31%) inPCa. The prevalence of genotypes of AA (wild-type), AG (heterozygous mutant) and GG (homozygous mutant) profilesfor the ATG16L1 Thr300Ala polymorphism were 35%, 40% and 25% respectively in BCa patients, and 32%, 40%and 28% respectively in healthy control groups. The G allele frequency was 0.53 for in BCa patients and the controlgroups. Conclusion: No association was found between ATG16L1 (Thr300Ala) polymorphism and patients with PCaand BCa in Turkish population we studied.}, keywords = {Autophagy,ATG16L1gene polymorphism,Prostate Cancer,bladder cancer}, url = {https://journal.waocp.org/article_67414.html}, eprint = {https://journal.waocp.org/article_67414_6dfca81c2043a4d013cca4e6b7590f2f.pdf} }