@article { author = {Widodo, Irianiwati and Dwianingsih, Ery Kus and Utoro, Totok and Anwar, Sumadi Lukman and Aryandono, Teguh and ., Soeripto}, title = {Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {9}, pages = {2461-2467}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.9.2461}, abstract = {Background: Breast carcinomas (BCs) are sub-classified according to the molecular characteristics into luminal andnon-luminal subtypes that clinically show different biological behavior, treatment and prognosis. BCs spread primarilythrough lymphatic vessels using cascade processes of lymphagiogenesis in which VEGF-C plays an important role duringlymph node metastasis. Prognostic value of VEGF-C in luminal and non-luminal BC is still unclear and has not beenstudied thoroughly to clarify and define prognosis and therapeutic monitoring. Aim: To define the prognostic value oflymphangiogenesis on survival rates of luminal and non-luminal subtypes BC. Materials and Methods: This studyapplied prospective cohort design, using 130 patients of invasive duct carcinoma of the breast, stage I-IIIA, fromSardjito General Hospital, Indonesia and subsequent longitudinal follow-up. Immunohistochemical staining wascarried out using anti-ER, -PR, -Her-2, VEGF-C, VEGFR-3 and D2-40 antibodies. The related clinicopathologiccharacteristics of BC patients and lymphangiogenesis determinants, including VEGF-C expression, were statisticallyanalyzed. Results: In non-luminal BC subtypes, VEGF-C expression (HR=0.04; 95% CI=0.01-0.41), lymph nodemetastasis (HR=0.14; 95% CI=0.04-0.55) and stage (HR=0.30; 95% CI= 0.02-0.76) were determined as independentprognostic factors on survival rates. However, the lymphangiogenesis determinants were not associated with the survivalrates of luminal BC subtypes. Conclusion: This study suggested that lymphangiogenesis affects survival rates ofnon-Luminal subtype rather than the luminal subtypes of BC.}, keywords = {Breast carcinoma,Luminal and non-luminal subtype,lymphangiogenesis,VEGF-C,survival}, url = {https://journal.waocp.org/article_67471.html}, eprint = {https://journal.waocp.org/article_67471_08bac44f40747b8de2e20b6c01c0eb37.pdf} }