@article { author = {Balmagambetova, Saule K and Tinelli, Andrea and Urazayev, Olzhas N and Sakieva, Kanshaiym Z and Koyshybaev, Arip K and Zholmukhamedova, Dinara A and Urazayeva, Saltanat T}, title = {HPV Types Distribution in General Female Population and in Women Diagnosed with Cervical Cancer Across Western Kazakhstan}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {20}, number = {4}, pages = {1089-1096}, year = {2019}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2019.20.4.1089}, abstract = {Objective: to detect the HPV types distribution both in general female population and in women with first diagnosedcervical cancer, including viral load in both groups. Methods: Qualitative detection and quantification of HPV wasperformed by PCR-Real time method based on the Russian equipment and test systems (“DNA-Technology” LLC,Russia). The DNA of low-risk (HPV 6, 11, 44) and possibly / potentially / high carcinogenic risk (HPV 16, 18, 26, 31,33 , 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82), a total of 21 types, were detected. Results: During the periodof 2014-2017 total 1,166 clinically healthy women were tested for HPV, as well as 73 women diagnosed with CaCx.Overall prevalence of HPV in female population was determined as 25.0% (95% CI 22.3;27.7, p = 0.05). Top-5 leadingHPV types: 16 (26.4%); 31 (10.1%); 51 (9.4%); 52 (9.0%); 6 (7.9%). Average viral load was 5.5±3.8 (CI 95% 5.1;5.9).In women diagnosed with CaCx ranking was as follows – 16 (54.1%), 31 (11.2%), 18 / 58 (5.1% each), 33 / 45 (4.1%each). Type 16 appeared to be one of the most significant risk factors of the CaCx development (p=0.00007, phi 0.35,Pierson’s X 2 15.9). Average viral load in patients with CaCx was 6.9±4.0 (95% CI 6.1;7.7). A reliable relationshipbetween the cancer staging and the viral load was found (p = 0.043, n = 73). Domination of type 16 calls for urgentneed the transition to HPV primary screening and resumption of immunization program discontinued in 2014. Thestudy is registered in ISRCTN registry, No. ISRCTN71514910 (01.02.2018).}, keywords = {human papillomavirus,types distribution,Viral load,Cervical cancer,Kazakhstan}, url = {https://journal.waocp.org/article_85923.html}, eprint = {https://journal.waocp.org/article_85923_35ab5b894ffa7602826762a2b9563700.pdf} }