@article { author = {Obaya, Ahmed and Mohammed, Amrallah and Rashied, Hanaa and Morsy, Adel Mahmoud and Osman, Gamal and Allam, Ahmed S and Elsayed, Ahmed and Harb, Ola and Elsayed, Walid S H}, title = {Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {22}, number = {4}, pages = {1025-1034}, year = {2021}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.31557/APJCP.2021.22.4.1025}, abstract = {Background: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn’t satisfactory. Methods: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed. Results: High Amphiregulin, PTEN and low P21 expression levels were associated with low tumor grade (p= 0.038 and 0.025 respectively), better response to anti-EGFR treatment (p <0.001), and favorable outcome {progression-free survival (PFS) and overall survival (OS)} (p <0.05). There was a direct relation between Amphiregulin and PTEN expressions (phi coefficient=+0.840), while there was an inverse relation between P21expression and both Amphiregulin (phi coefficient= -0.840) and PTEN expressions (phi coefficient = -1.000), which was statistically significant (P <0.001). Conclusion: High Amphiregulin and PTEN expression levels and low P21 expression levels were associated with better response to anti-EGFR therapy and improved survival outcome. They might be considered predictive markers of response to anti-EGFR therapy in mCRC.  }, keywords = {Anti-EGFR treatment, Metastatic Colorectal carcinoma,Amphiregulin, PTEN,p21}, url = {https://journal.waocp.org/article_89540.html}, eprint = {https://journal.waocp.org/article_89540_323a5d6491e30b6db68e1433844dd956.pdf} }