%0 Journal Article %T Expression Profiles of Loneliness-associated Genes for Survival Prediction in Cancer Patients %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 01/01/2014 %V 15 %N 1 %P 185-190 %! Expression Profiles of Loneliness-associated Genes for Survival Prediction in Cancer Patients %K Loneliness-associated genes %K expression profile %K hazards ratios %K cancer patients %K survival %R %X Influence of loneliness on human survival has been established epidemiologically, but genomic researchremains undeveloped. We identified 34 loneliness-associated genes which were statistically significant for highlonelyand low-lonely individuals. With the univariate Cox proportional hazards regression model, we obtainedcorresponding regression coefficients for loneliness-associated genes fo individual cancer patients. Furthermore,risk scores could be generated with the combination of gene expression level multiplied by correspondingregression coefficients of loneliness-associated genes. We verified that high-risk score cancer patients had shortermean survival time than their low-risk score counterparts. Then we validated the loneliness-associated genesignature in three independent brain cancer cohorts with Kaplan-Meier survival curves (n=77, 85 and 191),significantly separable by log-rank test with hazard ratios (HR) >1 and p-values <0.0001 (HR=2.94, 3.82, and1.78). Moreover, we validated the loneliness-associated gene signature in bone cancer (HR=5.10, p-value=4.69e-3),lung cancer (HR=2.86, p-value=4.71e-5), ovarian cancer (HR=1.97, p-value=3.11e-5), and leukemia (HR=2.06,p-value=1.79e-4) cohorts. The last lymphoma cohort proved to have an HR=3.50, p-value=1.15e-7. Lonelinessassociatedgenes had good survival prediction for cancer patients, especially bone cancer patients. Our studyprovided the first indication that expression of loneliness-associated genes are related to survival time of cancerpatients. %U https://journal.waocp.org/article_28571_4a49443958bc2e86aeb9ff99d09363d1.pdf