%0 Journal Article %T Meta Analysis of Treatment for Stage IE~IIE Extranodal Natural Killer /T Cell Lymphomas in China %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %D 2014 %\ 05/01/2014 %V 15 %N 5 %P 2297-2302 %! Meta Analysis of Treatment for Stage IE~IIE Extranodal Natural Killer /T Cell Lymphomas in China %K Extranodal natural killer/T cell lymphoma %K radiotherapy %K Chemotherapy %K RCT %K Meta Analysis %R %X Objective: To evaluate early treatment for extranodal natural killer/T cell lymphoma (ENK/TCL) in Chinaand provide reference for clinical treatment of these patients. Methods: Computer-based retrieval was performedin PubMed, CNKI, CBM, VIP and WanFang Data to search for randomized controlled trials (RCTs) of treatmentfor early ENK/TCL, and a meta-analysis was conducted with RevMan 5.0 software. Results: A total of 11 RCTs,including 871 patients, were selected, of which the first radiotherapy had a higher complete response (CR) thanthe first chemotherapy [OR=14.16, 95%CI (8.68, 23.10), P<0.00001] and CR was not different between combinedtreatment group and radiotherapy group [OR=1.86, 95%CI (0.47, 3.58), P=0.61], but long-term survival ratewas higher with combined treatment[OR=1.88, 95%CI (1.09, 3.19), P=0.02]. No difference in survival rate wasobserved between radio-chemotherapy and chemo-radiotherapy groups [OR=1.11, 95%CI (0.73, 1.69), P=0.63].Conclusions: Radiotherapy is of great significance in the treatment of early ENK/TCL, but combined therapycould further enhance long-term survival rate of patients. This conclusion still requires further confirmationusing RCTs with high quality and large sample size. %U https://journal.waocp.org/article_28916_d78d347ed295b8318c8606c8c933cae9.pdf