%0 Journal Article %T Expression of CDK6 in Oral Squamous Cell Carcinomas %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Andisheh-Tadbir, Azadeh %A Ashraf, Mohamad Javad %A Jeiroodi, Naghmeh %D 2018 %\ 04/01/2018 %V 19 %N 4 %P 1013-1016 %! Expression of CDK6 in Oral Squamous Cell Carcinomas %K CDK6 %K Squamous Cell Carcinoma %K immunohistochemistry %R 10.22034/APJCP.2018.19.4.1013 %X Background: CDK6 is the key factor in regulation of the cell cycle and essential for passage into the G1 phase. Italso plays an important role in the development of various tumors. In this cross-sectional study expression of the CDK6protein in oral squamous cell carcinoma (OSCC) and healthy oral mucosa of controls was assessed to determine relationswith malignant transformation and clinicopathologic factors. Method: A total of 60 samples, 45 from OSCCs and 15from healthy tissue, underwent immunohistochemistry for CDK6. Nuclear and cytoplasmic staining of keratinocyteswas considered as positive and the percentages of positive cells were calculated. Results: Expression of CDK6 wasdetected in 55.6% of OSCC samples (25 cases) and 13.3% of controls (2 cases), the difference being significant. Meanpercentage of CDK6 stained cells was 24.2±29.3 in the OSCC cases and 4.33±2.1 in the control group, again statisticallysignificant. No relationship was detected between CDK6 expression and clinicopathologic factors. Conclusion:Overexpression of CDK6 observed in OSCC points to a role for this protein in oral carcinogenesis. %U https://journal.waocp.org/article_57602_14ba43c4ef6a3d6a08d0d75e5b7e33d8.pdf