%0 Journal Article %T Association between Human Papillomavirus and Non-cervical Genital Cancers in Brazil: A Systematic Review and Meta-Analysis %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Peder, Leyde Daiane de %A Silva, Claudinei Mesquita da %A Boeira, Veridiana Lenartovickz %A Plewka, Jacqueline %A Turkiewicz, Mauricio %A Consolaro, Marcia Edilaine Lopes %A Sela, Vania %A Boer, Cinthia Gandolfi %A Gimenes, Fabricia %A Teixeira, Jorge Juarez Vieira %D 2018 %\ 09/01/2018 %V 19 %N 9 %P 2359-2371 %! Association between Human Papillomavirus and Non-cervical Genital Cancers in Brazil: A Systematic Review and Meta-Analysis %K human papillomavirus %K cancer %K Prevalence %K Brazil %R 10.22034/APJCP.2018.19.9.2359 %X Background: Human papillomavirus (HPV) infection is associated with cervical cancer; however, it iscontroversial whether it is involved in non-cervical genital cancers. Objective: This study aimed to evaluatearticles on the prevalence of HPV in penile cancer, vulvar cancer, colorectal cancer, prostate cancer and analcanal cancer in studies conducted in Brazil. Methods: The study was conducted in accordance with the PreferredReporting of Systematic Reviews and Meta-Analysis Statement. Comprehensive searches for HPV and cancer forthe years 2006 to 2016 were conducted in two databases (PubMed and Web of Knowledge) and Google Scholarsystem. We also tracked the references of all eligible articles to identify additional non-captured publications throughonline surveys. Results: Eighteen studies, with a combined sample size of 1,552 patients were analyzed. The overallprevalence of HPV was 43% (95% CI: 36–51%; p < 0.001). The pooled prevalence of HPV in penile cancer was 42%(95% CI: 32–55%; p < 0.001), in colorectal cancer it was 67% (95% CI: 64–70%; p < 0.001) and in vulvar cancer 43%(95% CI: 34–55%; p < 0.001). HPV 16 was the most prevalent in all sites evaluated, with prevalence estimated at 54%(95% CI: 44–66%; p < 0.001), followed by genotypes 33 (21%; 95% CI: 17–28; p < 0.001), 6 (15%; 95% CI: 8–26%;p < 0.001), 11 (13%; 95% CI: 5–32%; p < 0.001) and 18 (12%; 95% CI: 7–22%; p < 0.001), respectively. The pooledprevalence of single infection was 82% and infection by multiple genotypes of HPV was 22%. Conclusion: Our studydemonstrated a high prevalence of HPV in non-cervical genital cancers in Brazil, with predominance of genotype 16,providing evidence for the need for preventive and control measures to avoid future harm to the population. %U https://journal.waocp.org/article_67424_1e49834d96a5e674c7d49dd6bac17e78.pdf