%0 Journal Article %T Prevalence of Intestinal Parasitic Infection in Cancer, Organ Transplant and Primary Immunodeficiency Patients in Tehran, Iran %J Asian Pacific Journal of Cancer Prevention %I West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. %Z 1513-7368 %A Esteghamati, Abdoulreza %A Khanaliha, Khadijeh %A Bokharaei-Salim, Farah %A Sayyahfar, Shirin %A Ghaderipour, Masoomeh %D 2019 %\ 02/01/2019 %V 20 %N 2 %P 495-501 %! Prevalence of Intestinal Parasitic Infection in Cancer, Organ Transplant and Primary Immunodeficiency Patients in Tehran, Iran %K Immunodeficiency %K Transplant %K cancer %K opportunistic %K parasite infection %R 10.31557/APJCP.2019.20.2.495 %X Background: Intestinal parasitic infection in immunodeficient patients especially those with impaired cellularimmunity, like neoplasia, renal or heart transplant needs careful consideration. The objective of this study is to evaluatethe prevalence of intestinal parasites in different group of patients including cancer patients; organ transplants recipients,and primary immunodeficiency patients. Methods: Stool samples from 190 patients including 80 patients with PrimaryImmunodeficiency, 85 cancer patients and 25 organ transplant recipients were collected; a direct examination withPhosphate buffered saline (PBS) and formalin ether concentration was performed. The DNA was extracted fromparasitologically confirmed patients and nested PCR and sequencing was performed and new obtained sequences ofCryptosporidium parvum and Enterocytozoon bieneusi were compared with deposited ones. Results: In general, theprevalence of parasites was 26/80 (32.5%) in primary immunodeficiency, 22/85(25.9%) in cancer group, and 7/25(28%) in organ transplant. The prevalence of intestinal parasitic infections in primary immunodeficiency patientswere Blastocystis hominis 13 (16.2%), Giardia lamblia 10 (12.5%), Cryptosporidium 1(1.2%), Chilomastix mesnilii 1(1.2%), Dientamoeba fragilis 1(1.2%). Of 25 organ transplants, 6 (24%) Cryptosporidium sp were found, all of whichwere confirmed as Cryptosporidium parvum and one case of Microspora in a heart transplant recipient was confirmedas Enterocytozoon bieneusi by PCR sequencing. The predominant intestinal parasitic infection in cancer patients was19 (22.3%) Blastocystis hominis followed by two (2.3%) Giardia lamblia and one Dientamoeba fragilis 1 (1.1%).Conclusion: The high rate of infection with Blastocystis hominis was found in cancer patients especially colorectalcancer patients, so careful consideration should be given by physicians. Cryptosporidium sp was found to be the majorcause of parasitic intestinal infection in patients with organ transplant compared to primary immunodeficiency patients;so transplant recipients undergoing immunosuppressive therapy should be considered as a risk group for acquiringmicrosporidiosis and Cryptosporidium infection. %U https://journal.waocp.org/article_82235_2e78ab85e3af55dafe92c00799f51a99.pdf