TY - JOUR ID - 28844 TI - Ethanolic Extract from Derris scandens Benth Mediates Radiosensitzation via Two Distinct Modes of Cell Death in Human Colon Cancer HT-29 Cells JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 4 SP - 1871 EP - 1877 KW - radiosensitizer KW - Derris scandens benth KW - radiotherapy KW - apotosis mitotic catastrophe DO - N2 - Enhancing of radioresponsiveness of tumors by using radiosensitizers is a promising approach to increase theefficacy of radiation therapy. Recently, the ethanolic extract of the medicinal plant, Derris scandens Benth hasbeen identified as a potent radiosensitizer of human colon cancer HT29 cells. However, cell death mechanismsunderlying radiosensitization activity of D scandens extract have not been identified. Here, we show that treatmentof HT-29 cells with D scandens extract in combination with gamma irradiation synergistically sensitizes HT-29cells to cell lethality by apoptosis and mitotic catastrophe. Furthermore, the extract was found to decrease Erk1/2activation. These findings suggest that D scandens extract mediates radiosensitization via at least two distinctmodes of cell death and silences pro-survival signaling in HT-29 cells. UR - https://journal.waocp.org/article_28844.html L1 - https://journal.waocp.org/article_28844_b7a0aa7f5bd35750dde1d5f24c2eee59.pdf ER -