TY - JOUR ID - 29026 TI - Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2014 PY - 2014 VL - 15 IS - 7 SP - 2951 EP - 2957 KW - Gastric cancer KW - interleukin-4 gene KW - interleukin-8 gene KW - Polymorphism KW - risk KW - Case-control study DO - N2 - Background: Gastric carcinogenesis is a complicated process that involves environmental and genetic factorslike interleukin-4 (IL-4) and IL-8. Single nucleotide polymorphisms in their genes are associated with changedlevels of gene expression. Here, we investigated the association between IL4-590 C>T and IL8-251T>A andgastric cancer (GC) risk in Sichuan of Southwestern China. Materials and Methods: We surveyed the researchsubjects using a self-designed questionnaire with questions on demographic factors and putative risk factors.Approximately 2-5ml of whole blood was collected after field survey to analyze IL4-590 C>T and IL8-251T>Agenotypes using MALDI-TOF MS. Results: Our study recruited 308 pairs of GC patients and controls, including224 (72.7%) men and 84 (27.3%) women in each group. There were 99 cardia and 176 noncardia GC patients inthe case group. The case and control groups had an average age of 57.7±10.6 (mean±SD) and 57.6±11.1 years.GC patients reported a significantly greater proportion of family history of cancer (29.9% vs 10.7%, p<0.01)and drinking (54.6% vs 43.2%, p<0.01) than did controls. Variant genotypes of IL-4-590 C>T and IL-8-251 T>Awere not associated with overall GC risk (adjusted OR, 0.89; 95%CI, 0.61-1.28 for CT or CC vs TT; adjustedOR, 1.14; 95%CI, 0.86-1.79 for TA or AA vs TT). Stratification analysis of two SNPs for risk by subsites onlyfound that variant IL-8-251 TA or AA genotype was associated with increased noncardia GC risk (adjustedOR, 2.58; 95%CI, 1.19-5.57). We did not observe interactions between the IL-8-251 T>A genotype and smoking(adjusted OR, 0.38; 95%CI, 0.08-1.79) or drinking (adjusted OR, 0.36; 95%CI, 0.08-1.65) for risk of noncardiaGC. Conclusions: Our data indicate no association between the two SNPs of IL-4-590 and IL-8-251 with overallGC risk, while the IL-8-251 TA or AA genotype conferred risk of cardia GC. Our findings contribute to theevidence body for risk of SNPs associated with the development of gastric cancer in this region. UR - https://journal.waocp.org/article_29026.html L1 - https://journal.waocp.org/article_29026_a2eef00bcacc5bf8000581930763d957.pdf ER -