TY - JOUR ID - 31272 TI - Clinical Characteristics Associated with Long-term Survival in Metastatic Gastric Cancer after Systemic Chemotherapy JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 Y1 - 2015 PY - 2015 VL - 16 IS - 13 SP - 5433 EP - 5438 KW - Advanced gastric cancer KW - Chemotherapy KW - predictive factor KW - survival DO - N2 - Background: Systemic chemotherapy for patients with metastatic gastric cancer (MGC) is generallypalliative, although some patients experience long-term survival after treatment. Thus, we identified clinicalcharacteristics that are associated with long-term survival of patients with MGC after palliative chemotherapy.Materials and Methods: We retrospectively reviewed 514 MGC patients who received systemic chemotherapyat our institution from 2001 to 2008. To identify clinical predictors of survival beyond 2 years, multivariatelogistic regression analyses were performed, and 5-year survival rates were estimated among MGC patientsfollowing chemotherapy. Results: Among 514 patients, 96 (19%) and 16 (3%) survived beyond 2 and 5 years,respectively, and performance status of 0 or 1 (odds ratio [OR]=3.39; p=0.01), previous gastrectomy (OR=1.86;p=0.01), single metastatic site (OR=1.80; p=0.03), and normal alkaline phosphatase levels (OR=2.81; p<0.01)were identified as independent predictors of long-term survival. Of the 16 5-year survivors, six were alive at theend of the study and showed no evidence of disease despite cessation of chemotherapy. Conclusions: The presentdata demonstrate distinct clinical characteristics that are associated with long-term survival of MGC patients,and indicated that palliative chemotherapy can be curative in highly selected patients. UR - https://journal.waocp.org/article_31272.html L1 - https://journal.waocp.org/article_31272_553088f266fe2b8f823c539827861356.pdf ER -