TY - JOUR ID - 38760 TI - Lack of Evidence for a Relationship between High Risk Human Papillomaviruses and Breast Cancer in Iranian Patients JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Doosti, Masoud AU - Bakhshesh, Mehran AU - Zahir, Shokouh Taghipour AU - Shayestehpour, Mohammad AU - Karimi-Zarchi, Mojgan AD - Department of Animal viral Disease Research and Diagnosis, Razi Vaccine and Serum Research Institute, Karaj, Iran AD - Y1 - 2016 PY - 2016 VL - 17 IS - 9 SP - 4357 EP - 4361 DO - N2 - Background: Whether there is any relationship between human papilloma virus (HPV) and breast carcinoma is not clear. Some previous studies have indicated a possible role in oncogenesis in the breast. In this study, we therefore analyzed the presence of HPV infection in breast tissues of Iranian women from Yazd city. Materials and Methods: In a cross-sectional study, formalin-fixed paraffin-embedded tissues from 87 patients with breast cancer and 84 cases with breast fibrocystic lesions (control group) were selected from a tissue archive. Grade of tumors and fibrocystic tissues were determined by two pathologists. The nested-PCR method was performed for detection of HPVs in samples. HPV genotypes were determined by sequencing and the phylogenetic tree depicted by MEGA software. Results: Of the 87 women with breast cancer, 22.9% (20 isolates) had positive results for HPV DNA. In the control group no HPV was detected. The HPV genotypes in positive samples were HPV-16 (35%) HPV-18 (15%), HPV-6 (45%) and HPV-11 (5%). The data did not approved a significant correlation between tissue pathology of breast cancer and the HPV genotype frequency. Conclusions: The data did not provide any evidence for a role of high risk HPV types in oncogenesis in the breast. UR - https://journal.waocp.org/article_38760.html L1 - https://journal.waocp.org/article_38760_968130ad1b4ed00193c129f59b6cd4ae.pdf ER -