TY - JOUR ID - 40570 TI - Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Golmohammadi, Rahim AU - Rakhshani, Mohammad Hassan AU - Moslem, Ali Reza AU - Pejhan, Akbar AD - Department of Anatomy,Sabzevar University of Medical Sciences, Sabzevar, Iran AD - Y1 - 2016 PY - 2016 VL - 17 IS - 9 SP - 4527 EP - 4531 DO - N2 -   Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher’s exact test. Patient survival was analyzed after 4 years of follow-up using the Cox regression model. Results: PTEN gene expression was evident in 70 of 100 cnacer samples but was found at high levels in all non-cancer samples. There was an inverse significant relationship between PTEN gene expression and tumour stage or tumour grade (p<0.001). The expression of PTEN in invasive ductal tumours was lower than in non-invasive tumours. There was also an inverse significant relationship between the hazard of death and PTEN gene expression (p<0.001). In addition, there was an inverse significant relationship between tumour stage and hazard of death (p<0.001). Conclusion: These findings indicate that lack of PTEN gene expression can be a sign of a worse prognosis and poor survival in breast cancer cases. UR - https://journal.waocp.org/article_40570.html L1 - https://journal.waocp.org/article_40570_688f6fd693e316a859b4c1b0b791f9dc.pdf ER -