TY - JOUR ID - 64835 TI - Detection of HBV Genotype C in Hepatocellular Carcinoma Patients from North East India: a Brief Report JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Sarma, Manash P AU - Bhattacharjee, Minakshi AU - Kar, Premashis AU - Medhi, Subhash AD - PCR Hepatitis Laboratory, Department of Medicine, Maulana Azad Medical College, University of Delhi, New Delhi, India. AD - Department of Biotechnology, Assam down town University, Panikhaiti, Assam, India. Y1 - 2018 PY - 2018 VL - 19 IS - 7 SP - 1741 EP - 1746 KW - HBV KW - HCC KW - genotype C KW - North East India KW - South India and North India DO - 10.22034/APJCP.2018.19.7.1741 N2 - Background and Objectives: Newer genotypes of HBV have been reported from India. This study was aimed todetermine the circulating genotypes of HBV in hepatocellular carcinoma patients from three different geographicallocations of India. Methods: 141 HBV related HCC cases were included from three different hospitals across the country.Genotyping of HBV was performed by PCR using type specific primers specially designed in 70 cases. Samples ofinterest were confirmed by direct sequencing of the precore/core region of HBV genome. Results: Genotypes couldbe detected in 40 (57.14%) out of the 70 HBV DNA positive HCC cases by type specific primers. HBV genotype Dwas documented in 20 (50%), genotype A in 10 (25.0%) and genotype C in 10 (25.0%) of these HCC cases. GenotypeC of HBV was detected only in the samples from North East India. No significant difference was observed for thebiochemical profile. Conclusion: Although Genotype D is the major HBV genotype in India followed by A, detectionof HBV genotypes C in HCC patients indicates a changing epidemiology of the virus in India that may require regionbased management of the virus. UR - https://journal.waocp.org/article_64835.html L1 - https://journal.waocp.org/article_64835_4f83e3a15752fe6184383286eae832bf.pdf ER -