TY - JOUR ID - 67395 TI - The Sources of Essential Fatty Acids for Allergic and Cancer Patients; a Connection with Insight into Mammalian Target of Rapamycin: A Narrative Review JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Arshad, Zhila AU - Rezapour-Firouzi, Soheila AU - Mohammadian, Mahshid AU - Ebrahimifar, Meysam AD - Department of Pathology of Anatomy, School of Medicine, Baku University of Medical Sciences, Baku, Azerbaijan. AD - Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran. AD - Department of Biochemistry, School of Medicine, Urmia University of Medical Science, Urmia, Iran. AD - 4Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 9 SP - 2391 EP - 2401 KW - Polyunsaturated fatty acids KW - cancer KW - Allergy KW - Immune response KW - Thelper DO - 10.22034/APJCP.2018.19.9.2391 N2 - Background: Disturbance in essential fatty acids (EFA) metabolism plays a key role in autoimmune diseases, butEFA supplementation with sources of borage, evening primrose, hemp seed and fish oils was not effective in atopicand cancer diseases, as that seen in the case of multiple sclerosis. It seems that two complexes of the mammalian targetof rapamycin (mTOR) signaling, mTORC1 and mTORC2, are congruent with the two bases of the Traditional IranianMedicine (TIM) therapy, Cold and Hot nature, which are essential for the efficacy of functional oils for controllingimmune responses in autoimmune diseases. Methods: We searched PubMed database, Web of Science (WOS), GoogleScholar, Scopus and selected studies by predefined eligibility criteria. We then assessed their quality and extracted data.Results: The oils controlled by Cold or Hot nature may be helpful in maintaining homeostasis and preventing autoimmunediseases. In summary, studies of randomized controlled trials for allergy and cancer patients found no improvementin the signs or response to tests, despite a remarkable change in EFA fractions in the blood by supplementation withsources of borage, evening primrose, hemp seed and fish oils. In contrast, portulaca oleracea oil exhibited protectiveeffects by anti-inflammatory properties via the PI3K/Akt/mTORC2 pathway with a deviation immune response to Th1to treat atopic diseases and cancer. Conclusions: According to the concept of Traditional Iranian Medicine therapy, incontrast to Cold-nature oils, EFA supplementation with the sources of Hot-nature oilsis not suitable for the treatmentof atopic and cancerous diseases. UR - https://journal.waocp.org/article_67395.html L1 - https://journal.waocp.org/article_67395_2b186697bebacb87a5a3c855095cdce4.pdf ER -