TY - JOUR ID - 69121 TI - The Inflammatory Prognostic Index Predicts Cancer-Specific Outcomes of Patients with Resected Non-Small Cell Lung Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Tomita, Masaki AU - Ayabe, Takanori AU - Maeda, Ryo AU - Nakamura, Kunihide AD - Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan. AD - Department of Cardiovascular Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan. Y1 - 2018 PY - 2018 VL - 19 IS - 10 SP - 2867 EP - 2870 KW - inflammatory prognostic index KW - non-small cell lung cancer KW - Surgery KW - cancer-specific survival DO - 10.22034/APJCP.2018.19.10.2867 N2 - Background: Previous study developed a new inflammatory prognostic index (IPI) and found the prognostic valueof IPI for all stage non-small cell lung cancer (NSCLC). To the best of our knowledge, however, no studies regardingIPI in patients with resected NSCLC are available. Methods: Three hundred forty-one NSCLC patients who underwentsurgery at our institution were included. The IPI was calculated as C-reactive protein × neutrophil-to-lymphocyte ratio(NLR)/serum albumin. The optimal cut-off value was calculated by the Cutoff Finder. Univariate and multivariateanalyses were calculated by the Cox proportional hazards regression model. Results: The optimal cut-off value was5.237 for IPI. The IPI was associated with age, gender, smoking status, histology, pT status and serum CYFRA21-1level, but not pStage, pN status and serum carcinoembryonic antigen level. The 5-year cancer-specific survival ofpatients with low IPI was significantly better than that with high IPI (84.8% vs. 57.9%, p< 0.001). Furthermore, low IPIwas significantly associated with favorable cancer-specific survival in univariate (HR =0.326, 95% CI =0.212-0.494;p<0.001) and multivariate (HR =0.438, 95% CI =0.276-0.690; p=0.001) analyses. Conclusion: This is the first studyto demonstrate that IPI might serve as an efficient prognostic indicator in resected NSCLC. UR - https://journal.waocp.org/article_69121.html L1 - https://journal.waocp.org/article_69121_142bff32b1d4dc79716dd829a3d55b79.pdf ER -