TY - JOUR ID - 69796 TI - The Legacy of Mesenchymal Stem Cells in Vindicating the Clonal Evolution Model of Cancer JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Abtahi, Shabnam AU - Asadipour, Morvarid AU - Ghaderi, Abbas AD - Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Y1 - 2018 PY - 2018 VL - 19 IS - 8 SP - 2029 EP - 2030 DO - 10.22034/APJCP.2018.19.8.2029 N2 - Organogenesis and tumorigenesis seem to be followinga set pretty similar instructions and pathways and tumors,like any other organ, can be seen as the summation ofmany different cell types. However, unlike normal tissues,intercellular networks in cancer show high degreesof robustness and plasticity, employing other cellularnetworks in favor of their own growth1. The integratedhallmarks of cancer were first described by Hanahan andWeinberg in 20002, and was updated in 2011 by the samescientists3. They have described 10 hallmarks including:1) self-sufficiency in growth signals, 2) not responding toantigrowth signals, 3) unlimited proliferation, 4) resistingapoptosis, 5) genomic instability, 6) angiogenesis, 7)deregulated metabolism, 8) inflammation, 9) escapingimmune destruction, and 10) tissue invasion andmetastasis3, all of which have stood the test of time asbeing integral components of most forms of neoplasms.These unifying hallmarks are a reflection of the networkstructure of human cells dictating which genetic/epigeneticalterations are viable and in favor of tumor formationand progression. Among all the theories trying to explainthe origins and hallmarks of cancer since Hippocrates4,clonal evolution and the stem cell hypothesis are the twotheories that explain hallmarks of cancer the best5. Forthe purpose of this editorial our focus will be on the clonalevolution theory. UR - https://journal.waocp.org/article_69796.html L1 - https://journal.waocp.org/article_69796_0739e77e54e75531b109968922df3ccd.pdf ER -