TY - JOUR ID - 88715 TI - Determination of Cut Point in the Age of Colorectal Cancer Diagnosis Using a Survival Cure Model JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Abdollahi, Mahbobe AU - Kasiri, Nayereh AU - Pourhoseingholi, Mohamad Amin AU - Baghestani, Ahmad Reza AU - Esmaily, Habibollah AD - Department of Public Health, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran. AD - Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Biostatistics, Faculty of Health, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2019 PY - 2019 VL - 20 IS - 9 SP - 2819 EP - 2823 KW - colorectal cancer KW - Survival Analysis KW - survival cure model KW - change point KW - cut point DO - 10.31557/APJCP.2019.20.9.2819 N2 - Background and Objectives: Colorectal Cancer (CRC) is the fourth cancer-related cause of death worldwide.CRC is a multi-stage cancer, which is curable during the early stages of the disease. Therefore, determining the time ofcut-point existence could improve treatment planning and help directly allocate resources. This study aims to determinethe cut point in the age of CRC diagnosis. Methods: This study, covering the course 1985 to 2012, consisted of 345colorectal cancer patients registered in Taleghani Hospital, Tehran, Iran and followed up to 2013. The cut-point in theage of CRC diagnosis was obtained using a mixture cure model. The data were analyzed using SPSS and R, V. 20 and2.15.0, respectively. Results: The results showed that the cut point in the age of CRC diagnosis was 50 years. Basedon our estimation, 65% of the patients diagnosed with CRC at or younger than 50 were cured, while 31% of themdiagnosed older than 50 were cured, and the younger group had a better survival over the older group. Conclusion:Since access to a cut-point and analysis of created prognostic groups are important in screening and treatment planning,our results suggested that it is better to estimate the cut-point in the age of curable cancers in early stages via survivalcure models, and the cure rate would increase by CRC timely screening. UR - https://journal.waocp.org/article_88715.html L1 - https://journal.waocp.org/article_88715_f451e30f9eda53356c2300df9e0371cc.pdf ER -