TY - JOUR ID - 89033 TI - Incidence, Clinico-demographic Profiles and Survival Rates of Colorectal Cancer in Northern Malaysia: Comparing Patients Above and Below 50 Years of Age JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Wan Ibrahim, Nik Razima AU - Chan, Huan-Keat AU - Soelar, Shahrul Aiman AU - Azmi, Ahmad Najib AU - Mohd Said, Rosaida AU - Abu Hassan, Muhammad Radzi AD - Gastroenterology Unit, Department of Medicine, Ampang Hospital, Ampang, Selangor, Malaysia. AD - Clinical Research Center, Sultanah Bahiyah Hospital, Alor Setar, Kedah, Malaysia. AD - Faculty of Medicine and Health Sciences, Islamic Science University of Malaysia, Kuala Lumpur, Malaysia. Y1 - 2020 PY - 2020 VL - 21 IS - 4 SP - 1057 EP - 1061 KW - Colorectal Neoplasms KW - Early Detection of Cancer KW - Malaysia KW - survival rate DO - 10.31557/APJCP.2020.21.4.1057 N2 - Background: While the world witnesses an increasing trend of young-onset colorectal cancer (CRC), the information regarding the impact of age on CRC is limited in Malaysia. This study aimed to compare the incidence, clinic-demographic profiles and survival rates of CRC between patients above and under 50 years of age in northern Malaysia. Methods: This was a registry-based, cross-sectional study. All the CRC cases reported by 18 hospitals to the National Cancer Patient Registry - Colorectal Cancer (NCPR-CC) between January 2007 and December 2017 were included in the analysis. The patients were categorized by age into the above-50 and under-50 groups. The changes in the age-standardized incidence and mortality rates of both the age groups were determined using the time-series analysis, and the impact of age on the mortality risk was assessed using the Cox regression analysis. Results: Of the 6,172 CRC patients enrolled in the NCPR-CC, 893 (14.5%) were in the under-50 group. As compared with their older counterparts, the patients in the under-50 group were more likely to be female, be of Malay ethnicity, be non-smokers, have a family history of CRC, and present late for treatment. The age-standardized incidence and mortality rates of CRC in the under-50 group remained stable over the years, while a decreasing trend was clearly seen in the mortality rates of CRC in the above-50 group (p=0.003). Nevertheless, the two age groups also did not differ in the mortality risk (adjusted hazards ratio: 1.10; 95% CI: 0.90, 1.36). Conclusion: Young-onset CRC constituted a considerable proportion of CRC cases in Malaysia. However, in contrast with the findings of most studies, it demonstrated neither an uptrend in age-standardized incidence rates nor a higher mortality risk. Our findings suggest the need to upscale and lower the recommended age for CRC screening in Malaysia. UR - https://journal.waocp.org/article_89033.html L1 - https://journal.waocp.org/article_89033_7a4efe835a6c9baaca011ff21029224d.pdf ER -