TY - JOUR ID - 89235 TI - TFAP2B, AP-1 and JAZF1 Expression in Tissues of Papillary Thyroid Carcinoma Patients; Clinical, Pathological and Prognostic Values JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - A Abuderman, Abdulwahab AU - A Harb, Ola AU - M Gertallah, Loay AU - Makki Almansour, Nahlah AD - Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. AD - Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. AD - Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt. AD - Department of Biology, College of Science, University of Hafr Al Batin, Hafr Al Batin, Saudi Arabia. Y1 - 2020 PY - 2020 VL - 21 IS - 8 SP - 2415 EP - 2421 KW - TFAP2B KW - AP-1 KW - JAZF1 KW - Prognosis KW - immunohistochemistry DO - 10.31557/APJCP.2020.21.8.2415 N2 - Objective: Transcription factor activating protein 2 B (TFAP2 B) is a transcription factor that regulates many steps of embryogenesis, cell growth, apoptosis and recently oncogenesis and cancer progression. AP-1 is a transcription factor that is a downstream molecule of the MAPK signaling pathway. Juxtaposed with zinc finger gene 1 (JAZF1) is a recently detected transforming growth factor which has a role in carcinogenesis. Hence the present study aimed to assess those markers expression in tissues from patients with such cancer correlation their expression with clinic-pathological findings of the tumor and prognostic and follow-up findings of patients. Methods: We have collected tissue samples from papillary thyroid cancer patients and adjacent non-neoplastic tissues from 80 patients. We assessed the expression of TFAP2B, AP-1 and JAZF1 using immunohistochemistry. Results: Expression of TFAP2B was positively associated with lymph nodes metastases (p=0.003), distant metastases (p=0.002), recurrence of the tumor (p=0.002), unfavourable disease-free survival rate (p=0.003). AP-1 expression is positively associated with advanced stage (p=0.002), presence of extra-thyroid invasion (p=0.005), recurrence of the tumor (p=0.005), unfavorable disease-free survival rate (p=0.01). JAZF1 expression is negatively associated with huge tumor size (0.023), vascular invasion (p=0.007) and unfavorable overall survival rate (p=.030). Conclusion: High expression levels of TFAP2B and AP-1 and low expression levels of JAZF1 were associated with unfavourable pathological, prognostic parameters and dismal patient’s outcome.   UR - https://journal.waocp.org/article_89235.html L1 - https://journal.waocp.org/article_89235_a6b99cb897121473b7b36523fa1de2b4.pdf ER -