TY - JOUR ID - 89315 TI - Genetic Polymorphisms of Vitamin D Receptor Gene are Associated with Cervical Cancer Risk in Northeastern Thailand JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Phuthong, Sophida AU - Settheetham-Ishida, Wannapa AU - Natphopsuk, Sitakan AU - Ishida, Takafumi AD - Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. AD - Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand. AD - Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. Y1 - 2020 PY - 2020 VL - 21 IS - 10 SP - 2935 EP - 2939 KW - Genetic polymorphism KW - Vitamin D receptor KW - Cervical cancer DO - 10.31557/APJCP.2020.21.10.2935 N2 - Objective: This study aimed to explore whether VDR polymorphisms (Fok1, Apa1 and Taq1) are associated to the cervical cancer in Thai population. Materials and methods: Subjects of 204 cervical cancer patient and 204 age-matched healthy control were enrolled in the case-control study. VDR polymorphisms were detected by using real-time PCR. Haplotype analysis of three loci was applied to the obtained genotypes. Results: Significantly increased risk for cervical cancer was observed in carriers of TT genotype (p = 0.0388) and T allele (p = 0.0357) of Fok1 and TC genotype (p = 0.0001), CC genotype (p = 0.0160) and the C allele of Taq1 (p = 0.0001). Haplotype analyses revealed a significant correlation between C-T-C, T-G-C and T-T-C haplotypes and elevated risk for cervical cancer (OR = 2.06; 95%CI = 1.06-4.00; p = 0.0313, OR = 2.15; 95%CI = 1.22-3.80; p = 0.0078 and OR = 2.81; 95%CI = 1.53-5.16; p = 0.0006, respectively). Furthermore, haplotype carrying C allele of Taq1 (C-G-C + C-T-C + T-G-C + T-T-C) significantly increased cervical cancer risk with OR of 1.92 (95%CI = 1.32-2.79, p = 0.0006). Conclusion: Our finding revealed an association between VDR polymorphisms and cervical cancer risk. Taq1 C allele might be a molecular marker for cervical cancer development.   UR - https://journal.waocp.org/article_89315.html L1 - https://journal.waocp.org/article_89315_ed963a8ae799c791b8876eb1589929b1.pdf ER -