TY - JOUR ID - 90589 TI - Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients JO - Asian Pacific Journal of Cancer Prevention JA - APJCP LA - en SN - 1513-7368 AU - Anvarnia, Alireza AU - Panahizadeh, Reza AU - Zarredar, Habib AU - Asadi, Milad AU - Hashemzadeh, Shahriyar AU - Vatankhah, Mohammad Amin AU - Valizadeh, Hamed AU - Raeisi, Mortaza AD - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. AD - Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Department of Basic Oncology, Ege University, Institute of Health Sciences, Izmir, Turkey. AD - Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2023 PY - 2023 VL - 24 IS - 4 SP - 1407 EP - 1411 KW - SIK-1 KW - SIK-1-LNC KW - non-small cell lung cancer KW - Metastasis DO - 10.31557/APJCP.2023.24.4.1407 N2 - Background: Non-small-cell lung cancer (NSCLC) is currently the leading cause of mortality cancer. Introducing noninvasive approaches to diagnose NSCLC, especially at an early phase, might improve the disease’s prognosis. Long noncoding RNAs (lncRNAs), which are important regulators of the expression genes inside the cells, have been linked to a range of biological processes, such as cancer progression and metastasis, including NSCLC. The present work aims to determine the potential involvement of SIK-1-LNC and SIK-1 in NSCLC pathogenesis and the possible use of these molecules as novel biomarkers or therapeutic targets. Methods: In this work, the expression levels of SIK-1-LNC and SIK-1 in 50 pairs of NSCLC tumor and tumor marginal tissues were evaluated. So, after total RNA extraction and complementary DNA synthesis, the SIK-1-LNC and SIK-1 expression levels were evaluated by real-time PCR. In the study groups, clinical and pathological characteristics of the NSCLC patients were also examined. Results: Our findings showed that tumor samples had much lower levels of SIK-1 and SIK-1-LNC expression than tumor margin samples. SIK-1-LNC expression was correlated with SIK-1 levels in NSCLC samples. Interestingly, both stage and lymph node metastasis features of the tumor were associated significantly with SIK-1 and SIK-1-LNC expression levels. A ROC curve analysis indicated a biomarker index of 0.69 and 0.74 for SIK-1 and SIK-1-LNC, respectively. Conclusion: Collectively, our study emphasized the role of SIK-1-LNC and SIK-1 downregulation in NSCLC oncogenesis. Additionally, SIK-1 and SIK-1-LNC, particularly the latter, have shown remarkable potential to be utilized as new NSCLC biomarkers and therapeutic targets. UR - https://journal.waocp.org/article_90589.html L1 - https://journal.waocp.org/article_90589_11be490cf9d20aeeb708cb963dc8229b.pdf ER -