West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 2 1 2001 01 01 Intake Water for Prevention of Cancer: an Enzymological Lesson? 75 80 24029 EN Journal Article 1970 01 01 Extensive studies have so far been principally made using hydrophobic carcinogens in the field of chemicalcarcinogenesis. However, the species of glutathione S-transferases (GSTP1-1) linked to neoplasia of rat and humanwere recently shown to be selective for hydrophilic carcinogens such as acrolein and hydroxyalkenals (Satoh, 1998;Satoh et al., 1999) in accord with the finding of a water-network in the active site of the human GSTP1-1 by X-rayanalysis (Hu et al.; Ji et al., 1997). These results indicate that water-soluble carcinogens may be more significant thantheir hydrophobic counterparts in vivo. Of note, half-times for excretion of hydrophilic compounds are as short asseveral hrs, while those for hydrophobic ones are as long as several months or years. These available enzymologicaldata suggest on importance of consuming water to prevent cancer. https://journal.waocp.org/article_24029_f2b7bff244edeaca9de15a114d921ca5.pdf