West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 6 2 2005 02 01 Anti-tumour Promoting Activity of Diphenylmethyl Selenocyanate Against Two-stage Mouse Skin Carcinogenesis 181 188 24339 EN Journal Article 1970 01 01 Epidemiological, clinical and experimental evidence collectively suggests that Se in different inorganic and organic ‍forms provides a potential cancer chemopreventive agent, active against several types of cancer. It can exert preventive ‍activity in all the three stages of cancer: initiation, promotion and progression. Literature reports revealed that ‍organoselenocyanates have more potential as chemopreventive agents than inorganic forms due to their lower toxicity. ‍In our previous report we showed chemopreventive efficacy of diphenylmethyl selenocyanate during the initiation ‍and pre- plus post-initiation phases of skin and colon carcinogenesis process. The present study was undertaken to ‍explore the anti-tumour promoting activity of diphenylmethyl selenocyanate in a 7,12-dimethylbenz (a) anthracene ‍(DMBA)-croton oil two-stage skin carcinogenesis model. The results obtained showed significant (p<0.01) reduction ‍of the incidence and number of skin papillomas, precancerous skin lesions, along with significant (p<0.01) elevation ‍of phase II detoxifying enzymes (GST, Catalase and SOD) and inhibition of lipid peroxidation in liver and skin. ‍Thus, the present data strongly suggest that diphenylmethyl selenocyanate also has the potential to act as antitumour ‍promoter agent in a two-stage skin carcinogenesis mouse model, pointing to possible general efficacy. https://journal.waocp.org/article_24339_88e3406db1ce11b0d5c2118853ddb9ae.pdf