West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 7 4 2006 04 01 Risk Factors for Multiple Myeloma: Evidence from the Japan Collaborative Cohort (JACC) Study 575 581 24528 EN Journal Article 1970 01 01 This study assessed the association of multiple myeloma (MM) with age, body mass index (BMI, kg/m2), physicalactivity, occupational history, and medical history for a Japanese cohort of 46,157 men and 63,541 women aged 40-79 years followed during 1988-2003 years. Cox proportional hazard model was mainly used to estimate the age andsex adjusted hazard ratio (HR) of MM including 95% confidence interval (CI) for both sexes. Same model, adjustedfor age, was also used for each sex. In total, 98 MM deaths (men=49 and women=49) was observed for both sexes.Higher age groups (60-69 and 70-79 years) experienced significantly higher unadjusted HR of MM than the agegroup of 40-49 years. Men revealed significantly higher age-adjusted MM than women (HR=1.5; 95% CI=1.0-2.2).For both sexes, higher BMI of ≥30 kg/m2 (HR=2.8; 95% CI=1.0-7.7), walking ≤30 minutes/day (HR=2.0; 95% CI=1.2-3.4), worried about personal relationship in working place (HR=2.3; 95% CI=1.3-4.2), restricted own pace in workingplace (HR=1.9; 95% CI=1.0-3.4), and history of peptic ulcer (HR=1.7; 95% CI=1.0-2.7) significantly increased ageand sex adjusted MM risk. Some of the above-mentioned significant associations became insignificant for age adjustedsex specific analyses. However, these findings should be validated by further epidemiologic studies in Japan beforegeneralization. https://journal.waocp.org/article_24528_f23b035448bd9756f80ffa9760ebe8e6.pdf