West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 13 7 2012 07 01 Association Between XPD Asp312Asn Polymorphism and Esophageal Cancer Susceptibility: A Meta-analysis 3299 3303 26661 EN Journal Article 1970 01 01 Objective: To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asnpolymorphism and esophageal cancer (EC) susceptibility by meta-analysis. Methods: We searched PubMed up toApril 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were appliedto assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the ComprehensiveMeta-Analysis software, version 2.2. Results: Overall, the meta-analysis results suggested the XPD Asp312Asnpolymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20,95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR= 1.15, 95%CI =1.01-1.31, p=0.04]. In the subgroupanalysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI =1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI =1.02-1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed. Conclusions: This meta-analysisshows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasianpopulations and esophageal squamous cell carcinoma.

https://journal.waocp.org/article_26661_ec4a64c913d535d64a319577251d70a3.pdf