West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 13 10 2012 10 01 Prognostic Factors for Survival of Patients with Extensive Stage Small Cell Lung Cancer - a Retrospective Single Institution Analysis 4959 4962 26974 EN Journal Article 1970 01 01 The objective of this retrospective study was to investigate prognostic factors associated with survival ofpatients with extensive stage small cell lung cancer (ES-SCLC). Included were 200 patients admitted to theLiberation Army General Hospital with a diagnosis of ES-SCLC. The demographics of patients, diseasecharacteristics, pre-treatment biochemical parameters and therapeutic plan were assessed or evaluated.Univariate analysis found that second-line chemotherapy, radiotherapy, and no liver metastasis were associatedwith improved survival. Tumor response to first-line chemotherapy and normal initial hemoglobin levels werealso associated with a survival benefit (all P-values ≤ 0.0369). Multivariate Cox regression analysis indicatedthat liver metastasis and the total number of all chemotherapy cycles were independent prognostic factors ofsurvival. The morbidity risk in patients with liver metastasis was 2.52-fold higher than that in patients withoutliver metastasis (hazard ratio (HR)=2.52 (1.69-3.76); P<0.0001). However, one unit increase in the total numberof chemotherapy cycles decreased the risk of death by 0.86-fold (HR=0.86 (0.80-0.92); P<0.0001). Absence ofliver metastasis and ability of a patient to receive and tolerate multiple lines of chemotherapy were associatedwith longer survival. https://journal.waocp.org/article_26974_998c2eb428a67af15f3f72b213e3c229.pdf