West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 13 10 2012 10 01 Specific CCND1 G870A Alleles Associated with Breast Cancer Susceptibility: a Meta-analysis of 5,528 Cases and 5,353 Controls 5023 5025 26984 EN Journal Article 1970 01 01 Background: The Cyclin D1(CCND1) G870A polymorphism may be associated with breast cancer, but theevidence from individual studies is inconclusive. The aim of this study was to investigate the correlation betweenthe CCND1 G870A polymorphism and breast cancer risk in a meta-analysis. Materials and Methods: Wesearched Pubmed and analysed 11 articles on 5,528 cases and 5,353 controls before February 1, 2012. Results:we found there are significant association for AA versus GG and AA versus GA/GG. No significant associationswere found for GA versus GG, GA/AA versus GG. There are significant association for AA versus GG ,and AAversus GA/GG in Caucasians. We didn’t find any significant main effects for G870A polymorphism on breastcancer risk either in recessive or dominant models in Asians. Conclusion: This meta-analysis suggests that AAof the CCND1 G870A polymorphism is associated with breast cancer susceptibility.

https://journal.waocp.org/article_26984_cd206e327454133bc677d6063aecf9f8.pdf