West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 13 11 2012 11 01 Insertion/deletion (I/D) in the Angiotensin-converting Enzyme Gene and Breast Cancer Risk: Lack of Association in a Metaanalysis 5633 5636 27090 EN Journal Article 1970 01 01 Purpose: Breast cancer is an important cause of cancer-related death in women. Numerous studies haveevaluated the association between the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme(ACE) gene and breast cancer risk. However, the specific association is still controversial rather than conclusive.Therefore, we performed a meta-analysis of related studies to address this controversy. <br/><b>Methods</b>: PubMed,EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematicallysearched to identify relevant studies. A meta-analysis was performed to examine the association between theI/D polymorphism in the ACE gene and susceptibility to breast cancer. Odds ratios (ORs) and 95% confidenceintervals (95% CIs) were calculated. <br/><b>Results</b>: 10 separate studies of 7 included articles with 10,888 subjects onthe relation between the I/D polymorphism in the ACE gene and breast cancer were analyzed by meta-analysis,and our results showed no association between the I/D polymorphism in the ACE gene and breast cancer in totalpopulation and different populations. No publication bias was found in the present study. <br/><b>Conclusions</b>: The ACEI/D polymorphism may not be associated with breast cancer risk. Further large and well-designed studies areneeded to confirm this conclusion. https://journal.waocp.org/article_27090_d694cd0799fbf0e474048f5b4e962659.pdf