West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 14 2 2013 02 01 Effect of Botulinum Toxin A on Proliferation and Apoptosis inthe T47D Breast Cancer Cell Line 891 894 27443 EN Journal Article 1970 01 01 The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. TheT47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosiswere estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exertedgreater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be viaapoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependentapoptotic processes in the T47D breast cancer cell line. https://journal.waocp.org/article_27443_d0652017abb622c1c46a5cc2119e70b0.pdf