West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 14 5 2013 05 01 Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma 2699 2701 27683 EN Journal Article 1970 01 01 The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multipleeffector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) andRalGDS pathways. In the clinical field, K-ras oncogene activation is frequently found in human cancers and thusmay serve as a potential diagnostic marker for cancer cells in circulation. This mini-review aims to summariseinformation on Ras-induced oncogenesis and the clinical significance of K-ras. https://journal.waocp.org/article_27683_9459d8cae5d92b152879faa6ff990151.pdf