West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 14 5 2013 05 01 Associations of ABCB1 and XPC Genetic Polymorphisms with Susceptibility to Colorectal Cancer and Therapeutic Prognosis in a Chinese Population 3085 3091 27748 EN Journal Article 1970 01 01 Associations between ABCB1 and XPC genetic polymorphisms and risk of developing colorectal cancer (CRC)as well as clinical outcomes in CRCs with chemotherapy were investigated. A case-control study was performedon the ABCB1 C3435T, G2677T/A and XPC Lys939Gln polymorphisms in 428 CRC cases and 450 hospitalbased,age and sex frequency-matched controls using polymerase chain reaction-restriction fragment lengthpolymorphism (PCR-RFLP) assays. We observed that the ABCB1 3435CT or CC+CT variants were significantlylinked with increasing risk of developing CRC (adjusted OR (95% CI): 1.814 (1.237-2.660), P=0.0022; adjustedOR (95% CI): 1.605 (1.117-2.306), P=0.0102, respectively). Moreover, the distribution frequency of XPC ACgenotype or AC+CC genotypes also showed a tendency towards increasing the suscepbility for CRC (P=0.0759and P=0.0903, respectively). Kaplan-Meier curves showed that the ABCB1 C3435T variant was associated witha tendency toward longer progression-free survival (PFS) (n=343, Log-rank test: P=0.063), and the G2677T/Avariant genotypes (GT+TT+GA+AA) with a tendency for longer OS in postoperative oxaliplatin-based patients(n=343, Log-rank test: P=0.082). However, no correlation of the XPC Lys939Gln polymorphism was found withPFS and OS in patients with postoperative oxaliplatin-based chemotherapy (n=343). Our study indicated thatABCB1 polymorphisms might be candidate pharmacogenomic factors for the prediction of CRC susceptibility,but not for prognosis with oxaliplatin chemosensitivity in CRC patients. https://journal.waocp.org/article_27748_54f9ae958fa08d5672b50877bc303ac8.pdf