West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 14 9 2013 09 01 BCRP Expression in VX2 Rabbit Liver Tumours and its Effects on Tumour Recurrence, Metastasis and Treatment Tolerability 5089 5093 28082 EN Journal Article 1970 01 01 Objective: This study aimed to investigate the effects of BCRP expression on tumor recurrence, metastasisand treatment tolerability. Methods: A VX2 rabbit liver tumor model was established. Division was randomlyinto 4 groups: namely saline control group; A group, given hydration lipiodol; B group, Ad-p53; and C group,Ad-p53+hydration lipiodol. After the intervention, samples were collected to detect the BCRP, MMP-2, VEGFand PCNA. Results: The expression of BCRP, MMP-2, PCNA and VEGF in tumors in Group A had no significantdifference when compared with the control group, while in B and C group, the values were significantly lower(P < 0.05). BCRP positive expression in metastatic lesions significantly increased (P < 0.05), and was correlatedwith MMP-2 (X2=6.172, P = 0.0131). Conclusions: BCRP may play an important role in mediating liver cancermultidrug resistance to chemotherapy, and may be correlated with tumor recurrence and metastasis, whichleads to weakened treatment effect. Ad-P53 can down-regulate the expression of related genes, playing a role inmultidrug resistance reversal and increased sensitivity in liver cancer treatment.

https://journal.waocp.org/article_28082_1937f7e7d9b9667585d85f6443a86b58.pdf