West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 14 12 2013 12 01 Pretreatment Effects of Regular Aerobic Training on the IGF System and Hepatotoxicity Induced by Doxorubicin in Rats 7427 7431 28490 EN Journal Article 1970 01 01 Aims: To examine the pretreatment effects of regular aerobic training on the IGF system (IGF-I, IGFBP-3and IGF/IGFBP) and doxorubicin(DOX) induced hepatotoxicity in rats. Materials and Methods: Forty-eightmale rats were divided into groups:(1) control+placebo (2)control+DOX10 mg.kg-1 (3)control+DOX20 mg.kg-1(4)training+placebo (5) training+DOX10 mg.kg-1(6) training+DOX20 mg.kg-1. Hepatotoxicity was induced by DOXwith dosages of 10 and 20 mg.kg-1. The rats in groups 4, 5 and 6 performed treadmill running of 25-54 min/dayand 15-20 m/min, 5 days/wk for 6 wks. At the end of the aerobic training protocol, rats in the 1 and 4 groups,in the 2 and 5 groups and in the 3 and 6 groups received saline solution, DOX10 mg.kg-1and DOX20 mg.kg-1,respectively. Results: Administration of DOX20 mg.kg-1 caused a significant increase in IGF-1 and IGF-1/IGFBP-3,an insignificant decrease in IGFBP-3, as compared to the control+placebo group. However, after six weeks ofaerobic training and DOX treatment with 10mg.kg-1 and or/ 20mg.kg-1 an insignificant decrease in IGF-1, aninsignificant increase in IGFBP-3 and a significant decrease in IGF-1/IGFBP-3 were detected, in comparison toC+DOX10 and C+DOX20. Conclusions: Hepatotoxicity of doxorubicin is dose-dependent and pretreatment withregular aerobic training may improve DOX-induced hepatotoxicity by up-regulation of IGFBP3.

https://journal.waocp.org/article_28490_01e167851663058ea192897eac9be619.pdf