West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 15 1 2014 01 01 Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features 381 384 28603 EN Journal Article 1970 01 01 Background: Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. Theaim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients withbladder cancer. Materials and Methods: DKK-1 levels were determined in serum samples from 90 patients withbladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by usingenzyme linked immune-sorbent assay (ELISA). Results: Elevated preoperative DKK-1 levels were associatedwith tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). Conclusions: The results of ourstudy demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase inthe tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determinationof bladder cancer and the detection of patients with a likely poor clinical outcome.

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