West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 15 5 2014 05 01 Meta Analysis of Treatment for Stage IE~IIE Extranodal Natural Killer /T Cell Lymphomas in China 2297 2302 28916 EN Journal Article 1970 01 01 Objective: To evaluate early treatment for extranodal natural killer/T cell lymphoma (ENK/TCL) in Chinaand provide reference for clinical treatment of these patients. Methods: Computer-based retrieval was performedin PubMed, CNKI, CBM, VIP and WanFang Data to search for randomized controlled trials (RCTs) of treatmentfor early ENK/TCL, and a meta-analysis was conducted with RevMan 5.0 software. Results: A total of 11 RCTs,including 871 patients, were selected, of which the first radiotherapy had a higher complete response (CR) thanthe first chemotherapy [OR=14.16, 95%CI (8.68, 23.10), P<0.00001] and CR was not different between combinedtreatment group and radiotherapy group [OR=1.86, 95%CI (0.47, 3.58), P=0.61], but long-term survival ratewas higher with combined treatment[OR=1.88, 95%CI (1.09, 3.19), P=0.02]. No difference in survival rate wasobserved between radio-chemotherapy and chemo-radiotherapy groups [OR=1.11, 95%CI (0.73, 1.69), P=0.63]. Conclusions: Radiotherapy is of great significance in the treatment of early ENK/TCL, but combined therapycould further enhance long-term survival rate of patients. This conclusion still requires further confirmationusing RCTs with high quality and large sample size.

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