West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 15 18 2014 12 01 Clinical Efficacy and Prognostic Factors of Chemoreduction Combined with Topical Treatment for Advanced Intraocular Retinoblastoma 7805 7809 29298 EN Journal Article 1970 01 01 Objective: To explore the clinical efficacy and prognostic factors of chemoreduction combined with topicaltreatment of advanced intraocular retinoblastoma (RB). Materials and Methods: A total of 22 eyes from 17children with RB were selected for the study and treated with chemoreduction combined with topical cryotherapy,transpupillary thermotherapy (TTT) or episcleral plaque brachytherapy. Clinical and follow-up data wereretrospectively analyzed. Results: All children received 2~6 courses of chemoreduction treatment, (4.5±0.8courses on average); 17 eyes from 13 children were treated by chemoreduction combined with cryotherapy orTTT and 5 eyes from 4 children with chemoreduction combined with 125I episcleral plaque brachytherapy. Theeye retention rate was 81.8% (18/22), among which 38.9% (7/18) featured restored or maintained good vision.Postoperative follow-up period was 7 to 34 months, (18.6 ± 5.2 months on average). The recurrence rate was41.2% (7/17), among which 57.1% (4/7) were controlled by supplementing or appending cryotherapy or TTTtreatment during the follow-up period. The tumor basal diameter and thickness were significantly reduced(P<0.05 or P<0.01) after treatment. All children demonstrated different degrees of hair loss, 70.6% (12/17) withdifferent degrees of gastrointestinal reactions, 5.88% (1/17) with neutropenia and 11.8% (2/17) being seriouslyinfected during the chemotherapeutic treatment. Univariate and logistic regression analysis showed that tumorbasal diameter before treatment had a significant effect on the prognosis (P<0.01). Conclusions: Chemoreductioncombined with topical therapy can effectively control RB in the short term, and tumor basal diameter beforetreatment is an independent risk factor for prognosis.

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