West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 15 20 2014 12 01 Treatment Efficacy and Prognostic Factors for Huge HCC Based on Barcelona Clinic Liver Cancer Staging 8823 8828 30002 EN Journal Article 1970 01 01 Objective: To explore the most appropriate treatment for patients with hepatocellular cancer (HCC) >10 cmby using the Barcelona Clinic Liver Cancer (BCLC) classification. Materials and Methods: A total of 124 HCCpatients undergoing surgery were selected. Disease-free survival (DFS), overall survival (OS) and prognosticfactors were respectively assessed. Results: This study showed that the cumulative 1-, 3-, 5-year survival rateswere 79.7%, 59.8% and 41.6% in BCLC-A patients, 76.2%, 9.5% and 0% in BCLC-B patients and 44.9%, 0%and 0% in BCLC-C patients, respectively. The 1-, 3-, 5-year DFS rates were 49%, 24.5% and 9.1% in BCLC-Apatients, 7.5%, 0% and 0% in BCLC-B patients, respectively. No BCLC-C patients survived 1 year after surgery.Multivariate analysis indicated that hepatitis B surface antigen (HBsAg), vascular invasion, intra-hepaticmetastasis, curative resection, tumor rupture and pathologic differentiation were independent prognostic factors. Conclusions: Surgery is effective and safe for patients with HCC >10 cm with sufficient hepatic reserve.

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