West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 15 21 2014 12 01 microRNA-29b: an Emerging Player in Human Cancer 9059 9064 30040 EN Journal Article 1970 01 01 MicroRNAs (miRNAs) are ubiquitously expressed small, non-coding RNAs that negatively regulate geneexpression at a post transcriptional/translational level. They have emerging as playing crucial roles in cancerat all stages ranging from initiation to metastasis. As a tumor suppressor miRNA, aberrant expression ofmicroRNA-29b (miR-29b) has been detected in various types of cancer, and its disturbance is related withtumor development and progression. In this review, we summarize the latest findings with regard to the tumorsuppressor signatureof miR-29b and its regulatory mechanisms. Our review highlights the diverse relationshipsbetween miR-29b and its target genes in malignant tumors. MicroRNAs Gene expression tumor suppressor Gene Therapy https://journal.waocp.org/article_30040_d2076e0ffac889958f3d54810d1e9f54.pdf