West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 16 2 2015 02 01 Relation between Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-α Expression in Invasive Ductal Breast Cancer Patients and Correlations with Prognosis 823 829 30509 EN Journal Article 1970 01 01 The aim of the present study was to investigate the expression of the transcription factor Ki-67, ER, PR,Her2/neu, p21, EGFR, and TOP II-α in the tumor tissue of patients with invasive ductal carcinoma(IDC); inaddition, we examined correlations between these markers. Two hundred and sixteen IDC patients, who werenot previously been treated with chemo- or radiotherapy, were included in the study. All tumors were grade I-III.Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissuesections. Follow-up data were collected for 3 months to 10 years and analyzed for tumor recurrence, survival time,and prognostic risk factors. We determined Ki-67 expression correlates with the expression of ER, PR, HER-2,EGFR, and TOP-α, as well as lymph node involvement, high tumor grade, lymphovascular invasion, high tumorstage, and high TNM stage in IDC. Positive Ki-67 expression was a risk factor for rapid tumor recurrence andmay help tumor progression, leading to poor prognosis in IDC. Ki-67 was directly correlated with EGFR, TOPII-α, lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNMstage in the hormone receptor subtypes of breast cancer. In triple negative breast cancer, Ki-67 correlated withTOP II-α. Expression of Ki-67 correlated with that of ER, PR, HER-2, EGFR, TOP II-α, and p21. In addition,the biomarker Ki-67 has a role as a prognostic factor and indicates a poor prognosis in IDC. https://journal.waocp.org/article_30509_a6e05a6571ef8b4eba9a2278b4f2297a.pdf