West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 16 7 2015 07 01 Preventive and Therapeutic Effects of Quercetin on Experimental Radiation Induced Lung Injury in Mice 2909 2914 30849 EN Journal Article 1970 01 01 Objective: To investigate the protective effect of quercetin on radiation induced lung injury (RILI) andrelated mechanisms. Materials and Methods: Mice treated with radiation and/or quercetin were sacrificedat 1-8 weeks after irradiation under anesthesia. Lung tissues were collected for histological examination.Immunohistochemistry (IHC) and Western blotting were performed to detect the protein expression of nuclearfactor-κB (NF-κB) and Mitogen-activated protein kinases (MAPK) pathway. Results: Hematoxylin and eosin (HE)staining showed that radiation controls displayed more severe lung damage than quercetin groups, either highor low dose. Results of IHC and Western blotting demonstrated the expression level of NF-κB to be decreasedand that of an inhibitor of NF-κB (Iκb–α) to be increased by the quercetin intervention compared with theradiation control group. Numbers of JNK/SAPK, p38 and p44/p42 positive inflammatory cells were decreasedin the radiation+quercetin injection group (P<0.05). Conclusions: Quercetin may play a radio-protective rolein mice lung via suppression of NF-κB and MAPK pathways.

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