West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 16 9 2015 09 01 Aberrant Expression of HOXA5 and HOXA9 in AML 3941 3944 31013 EN Journal Article 1970 01 01 Background: Aberrant expression of HOX gene expression has been observed in cancer. The purpose of thisstudy was to investigate the alteration of HOXA5 and HOXA9 expression and their clinical significance in acutemeloid leukemia (AML). Materials and Methods: The expression of HOXA5 and HOXA9 genes of bone marrowsamples from 75 newly diagnosed AML patients and 22 healthy controls for comparison were examined by Realtimequantitative PCR (RQ-PCR) assay. Statistical analysis was conducted to evaluate HOXA5 and HOXA9expression as possible biomarkers for AML. Results: The results showed that the complete remission rate (52.6%)of the patients who highly expressed HOXA5 and HOXA9 was significantly lower than that (88.9%) in patientswho lowly express the genes (P=0.015). Spearmann correlation coefﬁcients indicated that the expression levelsfor HOXA5 and HOXA9 genes were highly interrelated (r=0.657, P<0.001). Meanwhile, we detected signiﬁcantcorrelations between HOXA9 expression and age in this limited set of patients (P=0.009). Conclusions: Theresults suggest a prognostic impact of increased expression of HOXA5 and HOXA9 in AML patients.

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