West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 16 13 2015 12 01 Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women 5421 5425 31270 EN Journal Article 1970 01 01 To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreationalphysical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control studywith 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structuredquestionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditionallogistic model. The distribution of GH1 genotypes was not significantly different between controls and cases(χ2=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activityshowed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95%CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A wasassociated with a decreased risk of breast cancer only among individuals of the BMI <25 (adjusted-OR=0.80;95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modifyany association between the GH1 T1663A polymorphism and breast cancer risk. https://journal.waocp.org/article_31270_791ae3a7287824e904e8595c5efbed89.pdf