West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 18 5 2017 05 01 Effects of Tobacco on Salivary Antioxidative and Immunologic Systems 1215 1218 46639 10.22034/APJCP.2017.18.5.1215 EN Fateme Arbabi-Kalati Oral Medicine Department, Zahedan University of Medical Sciences, Zahedan, Iran. Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Saeede Salimi Department of Biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Saeede Nabavi Dentist, Zahedan, Iran. Sahebdad Rigi Dentist, Zahedan, Iran. Masoud Miri-Moghaddam Students Scientific Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. Journal Article 2016 09 26 Background: Tobacco use is a harmful habit that causes adverse effects on oral health and plays a most important role in cancer development. Saliva is the first fluid that is exposed to tobacco and its antioxidant system plays an important role in anti-cancer potential; therefore, this study was designed to compare the antioxidant activity and immunologic system of saliva in tobacco users (smokers and smokeless tobacco users) and non-users. Materials and Methods: In this cross-sectional study, unstimulated saliva samples of 75 healthy individuals from three equal groups were investigated. Participants in group A had no periodontal disease and never smoked. Group B had no periodontal disease, never used smokeless tobacco, but had 3 years history of smoking at least 10 cigarettes daily. The twenty-five participants in group C had no periodontal disease and had 1 year history of chewing a 10-g tobacco packet daily. Activity of salivary superoxide dismutase (SOD), salivary glutathione peroxide, and salivary IgA concentration was evaluated. Data were analyzed using SPSS (version 18) and running Kruskal-Wallis test. Statistical significance was set at pResults: There were significant differences in the activities of the two enzymes and salivary IgA levels among the three groups. Activity of glutathione peroxide was higher in smokeless tobacco users. (P<0.001) while that of superoxide dismutase was higher in non-tobacco users than users (P<0.001). Salivary IgA levels were higher among smokeless tobacco users (p=0.04). Conclusion: Based on the results of the present study, the use of tobacco products decreases the antioxidative activity of the saliva and increases salivary IgA levels at the same time.

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