West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 18 7 2017 07 01 Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma 1947 1951 48502 10.22034/APJCP.2017.18.7.1947 EN Tahereh Nosratzehi Oral and Dental Disease Research Center, Department of Oral Medicine,Zahedan University of Medical Science, Zahedan, Iran. Ebrahim Alijani Clinical Immunolgy Research Center, Department of ImmunolgyZahedan University of Medical Science, Zahedan, Iran. Marziyeh Moodi Dentist, Zahedan University of Medical Science, Zahedan, Iran. Journal Article 2017 05 01 The aim of present study was to evaluate salivary matrix metalloproteinase-1 (MMP-1) , MMP-2, MMP-3 and MMP-13 levels in patients with oral lichen planus (OLP) and squamous cell carcinomas (SCC) as well as in healthy controls. Thirty cases of OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) clinically and histopathologically (group A), 30 with oral SCCs (group B), and 30 with no history of oral cancer, other lesions or lichen planus (group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. Unstimulated whole saliva was collected and laboratory measurement of salivary concentration of MMP-1, MMP-2, MMP-3 and MMP-13 was conducted by immuno-sorbent enzyme-linked methods. Data analysis was performed with Kruskal-Wallis and Mann-Whitney tests and Pearson’s correlation coefficients. In the present study, MMP-2 and MMP-13 levels were higher in oral SCC patients than in OLP cases and healthy individuals. More research is required to assess MMP links with tumor invasion.

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