West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 2 2018 02 01 Impact of Cyclin D1 and Heterogeneous Nuclear Ribonucleoprotein-K (HnRNP-K) on Urinary Bladder Carcinogenesis 513 519 57182 10.22034/APJCP.2018.19.2.513 EN Tarek Aboushousha Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt. 0000-0002-6686-2442 Olfat Hammam Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt. Noha Helal Pathology Departments,Theodor Bilharz Research Institute, Cairo, Egypt. 0000000304738857 Samir El Dahshan Urology Departments, Theodor Bilharz Research Institute, Cairo, Egypt. Journal Article 2017 10 03 Objective: This study aimed to investigate the expression of cyclin D1 and hnRNP-K in relation to the pathological<br />findings in bladder cancer including the type, grade, muscle invasion and bilharzial association. Methods: We studied<br />the immunoexpression; as regard the percentage, intensity and score of both cyclin D1 and hnRNP-K in different bladder<br />lesions including 10 cases of cystitis; 10 cases of carcinoma insitu (CIS), 20 cases of Squamous cell carcinoma (SCC)<br />and 66 cases of urothelial carcinoma (UC). Results: High expression of cyclin D1 was found in UC compared to other<br />groups (p<0.001) and in UC with low grade, non-muscle invasive and papillary tumors compared to their counterparts<br />(p<0.05, hnRNP-K expression was found in SCC compared to other groups (p <0.001) and in UC with high grade, muscle invasive<br />and non-papillary tumors compared to their counterparts (p<0.001each). Bilharzial-associated UC showed higher<br />expression of hnRNP-K percent (p<0.05) compared to non-bilharzial cases. Conclusion: This study elucidated a possible<br />contribution of cyclin D1 and hnRNP-K expression in the initiation and progression of urinary bladder carcinoma,<br />so, both of them can be used in predicting progression of urinary bladder carcinoma and to differentiate between UC<br />and SCC in high grade tumors. The possible role of both markers in immunotherapy deserves supplementary studies. https://journal.waocp.org/article_57182_1534ae6ce334389b33d761a3c5d01444.pdf