West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 2 2018 02 01 Genetic Polymorphism of the Glutathione S-transferase Pi 1 (GSTP1) and Susceptibility to Cervical Cancer in Human Papilloma Virus Infected Northeastern Thai Women 381 385 57460 10.22034/APJCP.2018.19.2.381 EN Sophida Phuthong Department of Physiology, Khon Kaen University, Khon Kaen, Thailand. 0000-0001-7960-5931 Wannapa Settheetham-Ishida Department of Physiology, Khon Kaen University, Khon Kaen, Thailand. HPV and EBV Carcinogenesis Research Group, Khon Kaen University, Khon Kaen, Thailand. 0000-0002-1668-1512 Sitakan Natphopsuk Chulabhorn International College of Medicine, Thammasat University,, Thailand. 0000-0001-9529-0247 Takafumi Ishida Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 1130033, Japan. Journal Article 2017 05 17 Objective: We aimed to investigate any association between a genetic polymorphism of the detoxification GSTP1<br />gene and risk of cervical cancer in northeastern Thailand. Materials and Methods: Genotyping of GSTP1 was performed<br />for 198 squamous cell cervical cancer (SCCA) patients and 198 age-matched healthy controls with the PCR-RFLP<br />method. Results: The respective frequencies of the G allele were 0.33 and 0.26 in the controls and cases, the difference<br />being significant (OR = 0.69 [95% CI: 0.50-0.95, p=0.0192]). Among women infected with high-risk types of HPV, being<br />a heterozygous carrier was associated with a reduced risk of cervical cancer (adjusted OR = 0.32 [95% CI: 0.12-0.91,<br />p=0.031]). Similarly, a decreased risk was observed in heterozygous women with a non-smoking partner (adjusted OR<br />= 0.27 [95% CI: 0.09-0.83, p=0.023]). Conclusions: GSTP1 polymorphism could influence susceptibility to cervical<br />cancer among northeast Thai women; either as a independent factor or in combination with high-risk HPV infection.<br />Dual-testing of HPV and the GSTP1 might prove an effective screening tool for cervical cancer. https://journal.waocp.org/article_57460_608ef7df85df4fb5a391f0b17eecf4f5.pdf