West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 4 2018 04 01 Identification of Key Candidate Genes and Pathways in Endometrial Cancer by Integrated Bioinformatical Analysis 969 975 59575 10.22034/APJCP.2018.19.4.969 EN Lihong Liu Department of Gynecological Ward, The Third Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China. Liaoning Provincial Key Laboratory of Follicle Development and Reproductive Health (Office of Science and Technology) , Jinzhou, China. 0000-0001-7643-4583 Fangxu Chen Department of Gynecological Ward, The First Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China. Aihui Xiu Department of Gynecological Ward, The First Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China. Bo Du Department of Gynecological Ward, The Third Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China. Liaoning Provincial Key Laboratory of Follicle Development and Reproductive Health (Office of Science and Technology) , Jinzhou, China. Hao Ai Liaoning Provincial Key Laboratory of Follicle Development and Reproductive Health (Office of Science and Technology) , Jinzhou, China. Department of Gynecological Ward, The First Affiliated Hospital ,Jinzhou Medical University, Jinzhou, China. Wei Xie Department of Gynecological Ward,Dongzhimen Hospital of Traditional Chinese Medicine,Beijing University of Chinese Medicine ,Beijing,China. Journal Article 2017 10 14 Endometrial Cancer is the most common female genital tract malignancy, its pathogenesis is complex, not yet<br />fully described. To identify key genes of Endometrial Cancer we downloaded the gene chip GSE17025 from the Gene<br />Expression Omnibus database. Differentially expressed genes (DEGs) were identified through the GEO2R analysis<br />tool. Functional and pathway enrichment analysis were performed for DEGs using DAVID database. The network of<br />protein–protein-interaction (PPI) was established by STRING website and visualized by Cytoscape. Then, functional<br />and pathway enrichment analysis of DEGS were performed by DAVID database. A total of 1000 significant differences<br />genes were obtained, contain 362 up-regulated genes and 638 down-regulated genes. PCDH10, SLC6A2, OGN,<br />SFRP4, TRH, ANGPTL, FOSB are down-regulated genes. The gene of IGH, CCL20, ELF5, LTF, ASPM expression<br />level in tumor patients are up-regulated. Biological function of enrichment include metabolism of xenobiotics by<br />cytochrome P450, MAPK signaling pathway, Serotonergic synapse, Protein digestion and absorption, IL-17 signaling<br />pathway, Chemokine signaling pathway, HIF-1 signaling pathway, p53 signaling pathway. All in all, the current study<br />to determine endometrial differentially expressed genes and biological function, comprehensive analysis of intrauterine<br />membrane carcinoma pathogenesis mechanism, and might be used as molecular targets and diagnostic biomarkers for<br />the treatment of endometrial cancer. https://journal.waocp.org/article_59575_3450d0036d9de8c98bed7543df9d72c5.pdf