West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter. Asian Pacific Journal of Cancer Prevention 1513-7368 19 7 2018 07 01 Immunohistochemical Evaluation of GLUT-3 and GLUT-4 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma 1779 1783 63642 10.22034/APJCP.2018.19.7.1779 EN Sthefane Gomes Feitosa Department of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil. Khalil Fernandes Viana Department of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil. Ealber Carvalho Macedo Luna Department of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil. Fábio Wildson Gurgel Costa Department of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil. 0000-0002-3262-3347 Roberta Barroso Cavalcante Department of Oral Pathology, Fortaleza University, Fortaleza, Brazil. Filipe Nobre Chaves Department of Pharmacology, School of Dentistry, Federal University of Ceara, Campus Sobral, Sobral, Brazil. 0000-0001-6345-8156 Hellíada Vasconcelos Chaves Department of Pharmacology, School of Dentistry, Federal University of Ceara, Campus Sobral, Sobral, Brazil. Karuza Maria Alves Pereira Departament of Morphology, School of Medicine, Federal University of Ceara, Brazil. 0000-0002-2880-6466 Journal Article 2017 06 25 Objectives: To evaluate immunohistochemically the expression of GLUT-3 and GLUT-4 in oral epithelial dysplasia<br />(OED) and the oral squamous cell carcinoma (OSCC) and assess possible involvement in the malignant transformation of<br />oral lesions. Methods: Tissue samples of 15 cases of OSCC and 15 of OED were subjected to immunohistochemistry<br />with anti-GLUT-3 and anti-GLUT-4 antibodies. Five fields of each case were analyzed, to provide percentages of<br />positive cells at 400X magnification. Result: GLUT-3 and GLUT-4 were positive in 100% of the analyzed samples,<br />the percentage immunolabeling for GLUT-3 ranging from 19% to 73% in the OED group and 10% to 89% in the OSCC<br />group. Positive immunolabeling for GLUT-4 ranged from 15.2% to 79.9% in the OSCC group and 27.1% to 92.6% in<br />the OED group. Statistical analysis with the Mann-Whitney test revealed that there was a higher expression of GLUT-4 in<br />the OED group than in the OSCC group (p=0.04) without any significant difference in the GLUT-3 expression (p=0.852).<br />Conclusion: GLUT-4 expression may indicate some role in oncogenic mechanisms which can determine a malignant<br />phenotype. Thus, it is suggested that further studies on the role of GLUT-3 in oral carcinogenesis be conducted. https://journal.waocp.org/article_63642_666c3143d6fbdc93fc224a166fd34f64.pdf